Extracts of the adrenal gland were first obtained by Polish physiologist Napoleon Cybulski in 1895. These extracts, which he called nadnerczyna ("adrenalin"), contained adrenaline and other catecholamines. American ophthalmologist William H. Bates discovered adrenaline's usage for eye surgeries prior to 20 April 1896. Japanese chemist Jokichi Takamine and his assistant Keizo Uenaka independently discovered adrenaline in 1900. In 1901, Takamine successfully isolated and purified the hormone from the adrenal glands of sheep and oxen. Adrenaline was first synthesized in the laboratory by Friedrich Stolz and Henry Drysdale Dakin, independently, in 1904.
The following Churches recognize all other mainstream Orthodox Churches, but are not recognized by any of them due to various disputes:
Abkhazian Orthodox Church
Bulgarian Orthodox Church Alternative synod
Croatian Orthodox Church (19421945)
Orthodox Church in Italy
Macedonian Orthodox Church Ohrid Archbishopric
Montenegrin Orthodox Church
Turkish Orthodox Church
Ukrainian Orthodox Church of the Kyivan Patriarchate
A hard-tail guitar bridge anchors the strings at or directly behind the bridge and is fastened securely to the top of the instrument. These are common on carved-top guitars, such as the Gibson Les Paul and the Paul Reed Smith models, and on slab-body guitars, such as the Music Man Albert Lee and Fender guitars that are not equipped with a vibrato arm.
In the 1960s, the tonal palette of the electric guitar was further modified by introducing effect units in its signal path, before the guitar amp, of which one of the earliest units was the fuzz pedal. Effects units come in several formats, the most common of which are the stompbox "pedal" and the rackmount unit. A stomp box (or pedal) is a small metal or plastic box containing the circuitry, which is placed on the floor in front of the musician and connected in line with the patch cord connected to the instrument. The box is typically controlled by one or more foot-pedal on-off switches and it typically contains only one or two effects. Pedals are smaller than rackmount effects and usually less expensive. "Guitar pedalboards" are used by musicians who use multiple stomp-boxes; these may be a DIY project made with plywood or a commercial stock or custom-made pedalboard.
A rackmount effects unit may contain an electronic circuit nearly identical to a stompbox-based effect, but it is mounted in a standard 19" equipment rack, which is usually mounted in a road case that is designed to protect the equipment during transport. More recently, as signal-processing technology continuously becomes more feature-dense, rack-mount effects units frequently contain several types of effects. They are typically controlled by knobs or switches on the front panel, and often by a MIDI digital control interface.
Typical effects include:
Effects such as stereo chorus, phasers and flangers, which shift the pitch of the signal by a small and varying amount, creating swirling, shimmering and whooshing noises
Effects such as octavers, which displace pitch by an exact musical interval
Distortion, such as transistor-style fuzz, effects incorporating, emulating vacuum tube distortion or overdrive
Filters, such as wah-wah
Envelope shapers, such as compression/sustain or volume/swell
Time-shift effects, such as delay and reverb