An extract on #tropicalvibes
Collagen has an unusual amino acid composition and sequence:
Glycine is found at almost every third residue.
Proline makes up about 17% of collagen.
Collagen contains two uncommon derivative amino acids not directly inserted during translation. These amino acids are found at specific locations relative to glycine and are modified post-translationally by different enzymes, both of which require vitamin C as a cofactor.
Hydroxyproline derived from proline
Hydroxylysine derived from lysine - depending on the type of collagen, varying numbers of hydroxylysines are glycosylated (mostly having disaccharides attached).
Cortisol stimulates degradation of (skin) collagen into amino acids.
Calvin and Hobbes follows the humorous antics of Calvin, a precocious, mischievous and adventurous six-year-old boy, and Hobbes, his sardonic stuffed tiger. Set in the contemporary suburban United States, the strip depicts Calvin's frequent flights of fancy and his friendship with Hobbes. It also examines Calvin's relationships with family and classmates, especially the love/hate relationship between him and his classmate, Susie Derkins. Hobbes' dual nature is a defining motif for the strip: to Calvin, Hobbes is a living anthropomorphic tiger; all the other characters see Hobbes as an inanimate stuffed toy. Though the series does not mention specific political figures or current events, it does explore broad issues like environmentalism, public education, philosophical quandaries, and the flaws of opinion polls.
At the height of its popularity, Calvin and Hobbes was featured in over 2,400 newspapers worldwide. In 2010, reruns of the strip appeared in more than 50 countries, and nearly 45 million copies of the Calvin and Hobbes books had been sold.
Calvin's unnamed mother and father are typical middle-class parents. Calvin's father is a patent attorney (like Watterson's own father) and his mother is a stay-at-home mom. Both remain unnamed except as "Mom" and "Dad," or pet names such as "honey" and "dear" between themselves. Watterson says, "As far as the strip is concerned, they are important only as Calvin's mom and dad." Like many other characters in the strip, they are relatively down to earth and their sensible attitudes serve as a foil for Calvin's outlandish behavior.
Watterson says some fans were angered by the way Calvin's parents thought of Calvin. This is shown when Calvin's father claimed that he wanted a dachshund instead of Calvin, and often tries to "deny" that Calvin is his biological son:
Dad: Someday I'm going to get my DNA checked to see if he's really my kid.
Mom: Take my word for it.
Dad: I just know some nurse switched the bassinets.
Calvin's parents are not above some outrageous behavior of their own. For example, Calvin asks for a cigarette and his mother gives him one to teach him a lesson. Calvin's father tells Calvin sarcastic lies when asked a straight question, and Calvin often believes them:
Watterson defends what Calvin's parents do, remarking that in the case of parenting a kid like Calvin, "I think they do a better job than I would." Calvin's father is overly concerned with "character building" activities in a number of strips, either in the things he makes Calvin do or in the masochistic eccentricities of his own lifestyle. For example, Calvin's father is shown coming home from an early morning run in the snow, which he follows with a bowl of plain oatmeal.
Calvin's father has a brother named Max, who lives out of state. Watterson introduced him in a week of strips but said he later regretted the idea. Although Watterson said the idea of having Max in the strip was to set up potential future storylines, he realized that his intent to have the parents remain nameless worked against him because Max could not refer to either one by name. This was cited as one of the main reasons Max never reappeared.