Puma (car manufacturer), a Brazilian brand of sports cars
Puma (kit car company), an Italian brand of dune buggy and sports kit-car
Personal Urban Mobility and Accessibility, a prototype electric vehicle designed by Segway and General Motors
Ford Puma, a sports car
Puma (AFV), an Italian family of armoured fighting vehicles
Puma (IFV), a German infantry fighting vehicle
Puma (IDF), an Israeli combat engineering vehicle
PUMA M26-15, a South African armoured personnel carrier
'Puma', also known as a 'Warthog', from the Halo series of video games
SdKfz 234/2, a variant of the Schwerer Panzersphwagen, a German armored car of World War II
AMD Puma, a mobile computing platform
Programmable Universal Machine for Assembly, an industrial robot arm
Mac OS X 10.1, an operating system codenamed "Puma"
Protected User Mode Audio, a DRM technology in Microsoft operating systems
Puma (Hewlett-Packard), a codename for the HP 1000CX palmtop PC
Robert Puma, Imran series character and Grade-One Section's agent
PUMAS, people who have graduated, attended or are otherwise associated with Saint Joseph's College in Rensselaer, IN.
Puma Swede, a Swedish pornographic actress
T.J. Perkins, American professional wrestler
Jos Luis Rodrguez (singer), Venezuelan singer and actor, nicknamed "El Puma"
Jos Luis Carranza, Peruvian football player, nicknamed "El Puma"
Puma (band), a Norwegian experimental free impro jazz ensamble
Puma (comics), a comic book character
People United Means Action, a political action committee during the 2008 US presidential election
p53 upregulated modulator of apoptosis, a gene
Public Use Micro Data Sample Area, a census subdivision of US states
Paediatric-use marketing authorisation by the European Medicines Agency