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Dallas has many hospitals and a number of medical research facilities within its city limits. One major research center is the Dallas Medical District with the UT Southwestern Medical Center in the Stemmons Corridor, along with the affiliated UT Southwestern Medical School. The health care complex includes within its bounds Parkland Memorial Hospital, Children's Medical Center, William P. Clements University Hospital (formerly St. Paul University Hospital), and the Zale Lipshy University Hospital. Dallas also has a VA hospital in the southern portion of the city, the Dallas Veterans Affairs Medical Center. The center is home to a Consolidated Mail Outpatient Pharmacy (CMOP), part of an initiative by the Department of Veterans Affairs to provide mail-order prescriptions to veterans using computerization at strategic locations throughout the United States. Other hospitals in the city include Baylor University Medical Center in East Dallas, Methodist Dallas Medical Center in Oak Cliff, Methodist Charlton Medical Center near Duncanville, Medical City Dallas Hospital and Presbyterian Hospital in North Dallas, and the Texas Scottish Rite Hospital for Children in Oak Lawn.

Dallas is at the confluence of four major interstate highwaysInterstates 20, 30, 35E, and 45. The Dallas area freeway system is set up in the popular hub-and-spoke system, shaped much like a wagon wheel. Starting from the center of the city, a small freeway loop surrounds Downtown, followed by the Interstate 635 loop about 10 miles (16 km) outside Downtown, and ultimately the tolled President George Bush Turnpike. Inside these freeway loops are other boulevard- and parkway-style loops, including Loop 12 and Belt Line Road. Another beltway around the city upwards of 45 miles (72 km) from Downtown is under plan in Collin County. Radiating out of Downtown Dallas' freeway loop are the spokes of the area's highway systemInterstates 30, 35E, and 45, U.S. Highway 75, U.S. Highway 175, State Spur 366, the Dallas North Tollway, State Highway 114, U.S. Highway 80, and U.S. Highway 67. Other major highways around the city include State Highway 183 and State Spur 408. The recently completed interchange at the intersection of Lyndon B. Johnson Freeway (Interstate 635) and Central Expressway (U.S. Highway 75) contains 5 stacks and is aptly called the High Five Interchange. It is currently one of the few 5-level interchange in Dallas and is one of the largest freeway interchanges in the United States. The following is a list of the freeways and tollways in the Dallas/Ft. Worth area:

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