After graduating from college, Moukhin worked in a project institute. From 1985 to 1986 he attended classes at the studio of prominent Moscow photographer Alexander Lapin. He later spent several years working with samizdat rock musicians.
In 1987, Moukhin had his first personal exhibition at the Moscow State University. Since 1989 he has been working as an independent photographer.
Moukhin is known for his photographs of Soviet rock musicians of the perestroika period, including Viktor Tsoi, Boris Grebenshikov and Petr Mamonov. His projects have included The Soviet Monuments, The Soviet Bench, Fragments of Evident Propaganda, The Soviet Children's Playgrounds, Night Moscow, Girls, Moscow in Winter: Heavy Breath of Winter and The Province. The Nizhniy Novgorod vacation. Some of the photographs from these projects were shown at the Tretyakov gallery and La Maison Rouge in Paris in 2007. In the mid-1990s, Moukhin worked on documentary projects about Moscow and provincial Russia.
In 1996, he was a guest speaker at the international festival InterFoto in Moscow. In 1999, Moukhin received a grant from the Paris Mayor's office to work on a project titled "Lovers in Paris" sponsored by FNAC (Fonds national d'art contemporain) and the French Committee to commemorate the year 2000.
Mukhin usually uses rangefinder cameras including the Leica M6 and black and white film.
His work has been published in many Russian magazines and in foreign editions such as Rolling Stone, GEO, Elle, Vogue, Le Monde, Libration, Esquire, and Time among others.
Avoir 20 ans a Moscou. Paris: Editions Alternatives, 1998. ISBN 2-86227-170-5. Text by G.Saffrais.
Igor Moukhine. Paris: Carre Noir; Moscow: Moscow House of Photography, 2000. Text by Olga Sviblova.
Wien Vienna = . , Krinzinger Projekte, Vienna, 2004. Text by Peter Weiermair.
Igor Moukhin. Colorado State University, Fort Collins, USA: Hatton Gallery, 2004. Text by A. D. Coleman.
Born in the SSSR. Moscow: L. Gusev, 2005. Text by Ekaterina Degot and Steve Yates.
My Moscow. Schilt Publishing, 2012.
Mein Moskau: Fotografien 19852010. Bern: Benteli, 2012. ISBN 978-3-7165-1722-2.
2012: Igor Moukhin. Photographies 1987 2011. Paris: ditions Loco, 2012. ISBN 978-2-919507-12-2. Text by Christian Gattinoni and Bahia Allouache.
1995 Vision of Russia. Naarden Fotofestival, Grote Kerk, Naarden, Netherlands.
1996 Life in the City. Latvian Museum of Photography, Riga, Latvia.
1997 Soviet Epoch: Benches and Monuments. Photohouse, Riga, Latvia.
1998 Moscou la Jenne. Bibliothque Elsa-Triolet, Pantin, France.
1999 Igor Moukhin. Galerie Carre Noir, Paris, France.
2000 La jeunesse a Paris. (Mois de la photo a Paris 2000), Galerie Carre Noir, Paris.
2001 Light. Moscow.
2002 Moscow. International Photography Festival, Pingyao, China.
2002 Moscou Paris. Moscow House of Photography, Moscow, Russian Museum (2003).
2003 Moskauer Jugent im 3. Jahrtausent. Moskauer Tage in Berlin, Kulturbrauerei, Berlin.
2003 Contemporary Moscow Photography. Anahita Gallery, Santa Fe, USA.
2003 Wien Moscow. Krinzinger Projekte, Vienna.
2004 I.Moukhin. Contemporary Russian Photography. The Camera Obskura Gallery, Denver, USA.
2004 I.Moukhin: Visions of Contemporary Russia. Hatton Gallery, Colorado State University, Fort Collins, USA.
2004 Generation next. Auditorium parco della musica. Festival Russo, Rome.
2008 Igor Moukhin, Stockholm International Fairs, Sweden.
2008 Igor Moukhin, CM ART, Paris
2012 La mia Mosca. Festival Fotografia Europea 2012. San Pietro Cloisters. Reggio Emilia, Italy.
2013 Rtrospective La Russie d'Igor Moukhin, photographies de 1987 2012. Grand Rservoir de L'Hpital de Bictre, Le Kremlin-Bictre. Festival RussenKo 2013, France.