The freeway enters Tennessee directly in the Chattanooga metropolitan area, where it intersects with I-24. Exiting Chattanooga to the northeast, I-75 passes through an area known for dense fog. Twelve people were killed and 42 were injured in a 99-vehicle accident on that stretch of I-75 in heavy fog on December 11, 1990. I-75 does not meet any other highways until it overlaps Interstate 40 near Farragut and heads eastbound. Together, they enter the outskirts of Knoxville, where I-75 overlaps itself with a different road, this time I-640, but only for a short time. When the two meet I-275, I-75 encounters some of its highest points of elevation through the Cumberland Mountains and Cumberland Plateau region, cutting through the uppermost peaks and ridges of the mountains.
Immediately after entering Cincinnati, I-71 separates from I-75, taking a more east and northeasterly routing through the city, while I-75 remains generally northbound throughout the metropolitan area. I-74 westbound, Ohio State Route 562 (SR 562) eastbound, and SR 126 all intersect the freeway as it makes its way northward. In Arlington Heights, a Cincinnati suburb, I-75 sees a carriageway split for a few miles. After another interchange with the I-275 beltway, the freeway continues in the metropolitan area, passes through Middletown and heads toward Dayton, where I-675, I-70, and U.S. Route 35 (US 35), have interchanges. The intersection of I-75 with I-70 is known as the Freedom Veterans Crossroads. After exiting the city of Dayton, I-75 makes its way northbound through Ohio, passing through the smaller cities of Troy, Wapakoneta, Lima, Findlay and Bowling Green before finally reaching Toledo, located on the Michigan border. I-475 is met first south of the city, and then the cross-country highways of I-80/I-90/Ohio Turnpike. I-475 then meets with I-75 again. I-280 is the last major junction in Ohio; the freeway crosses into Michigan soon afterward.
Lazarevsky City District lies to the northwest from the city center; the 2010 Census showed the population of 63,894 people. It is the largest city district by area, covering some 1,744 square kilometers (673 sq mi) and comprising several microdistricts:
Lazarevskoye, 59 km (37 mi) from the city center, contains a delphinarium, an old church (1903), and a new church (1999). The settlement was founded as a Russian military outpost in 1839 and was named after Admiral Mikhail Lazarev.
Loo, 18 km (11 mi) from the city center, was once owned by Princes Loov, a noble Abkhazian family. The district contains the ruins of a medieval church, founded in the 8th century, rebuilt in the 11th century, and converted into a fortress in the Late Middle Ages.
Dagomys, 18 km (11 mi) from the city center, has been noted for its botanical garden, established by order of Nicholas II, as well as tea plantations and factories. A sprawling hotel complex was opened there in 1982. Dagomys adjoins Bocharov Ruchey, a dacha built for Kliment Voroshilov in the 1950s, but later upgraded into a country residence of the President of Russia, where he normally spends his vacations and often confers with leaders of other states.
Golovinka is a historic location at the mouth of the Shakhe River. Formerly marking the border between the Ubykhs and the Shapsugs, the settlement was noted by Italian travelers of the 17th century as Abbasa. On May 3, 1838, it was the site of the Subashi landing of the Russians, who proceeded to construct Fort Golovinsky where many convicted Decembrists used to serve. The fort was intentionally destroyed by Russian forces at the beginning of the Crimean War, so as to avoid its capture by the enemy.
Fort Godlik, of which little remains, had a turbulent history. It was built at the mouth of the Godlik River in the Byzantine period (5th to 8th centuries), was destroyed by the Khazars and revived by the Genoese in the High Middle Ages.